Over the course of the past year, the SARS-CoV-2 virus drastically altered the way that virtually everyone lived their lives – from the workplace to home and beyond. With the pandemic came research and development (and ultimately deployment) of technologies designed to fight the virus and keep people safe and healthy in the environments where they live, work, and play. While not new, one such technology is germicidal ultraviolet (UV) disinfection. Interest in this specialized area of lighting has skyrocketed in popularity due to the pandemic – a trend that is unlikely to fade any time soon. This collection of articles in this e-book highlights the benefits, drawbacks, safety considerations, and more surrounding this flourishing technology.